P.R.O. METABOLIC MANAGEMENT

Provider-Guided Metabolic & Weight Management

Personalized Treatment + 30-Day Monitoring + Body Composition Tracking + Nutrition + Supplement + Laboratory Support

Program Overview

PRO's approach to metabolic and weight management is built around medical oversight, objective data, and individualized treatment rather than simply selecting a medication from an online store.

Available treatment pathways may incorporate:

• Comprehensive medical consultation
• Individualized weight and body-composition goals
• Prescription medication management when medically appropriate
• 30-day interval monitoring
• Body composition monitoring
• Sleep, activity, and recovery data
• Nutrition guidance
• Muscle-preservation strategies
• Targeted supplementation
• Laboratory testing when indicated
• Hume wearable and Body Pod integration through PRO Foundations
• Ongoing treatment adjustments based on response and tolerability

Prescription treatment is never guaranteed and requires an appropriate medical consultation and provider determination before treatment can be prescribed.

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Understanding the Options

Several different incretin-based molecules may be discussed during metabolic treatment.

Although these compounds are frequently grouped together, they act through different receptor pathways and have different regulatory statuses.

Semaglutide

Semaglutide is a GLP-1 receptor agonist.

GLP-1 signaling is involved in appetite regulation, satiety, gastric emptying, and glucose regulation.

Semaglutide has been extensively studied for chronic weight management. In the STEP 1 randomized trial, adults with overweight or obesity received once-weekly semaglutide or placebo, in addition to lifestyle intervention, for 68 weeks.

Tirzepatide

Tirzepatide is a dual GIP and GLP-1 receptor agonist.

By acting through both GIP and GLP-1 receptor pathways, tirzepatide targets multiple pathways involved in appetite and metabolic regulation.

The SURMOUNT-1 phase 3 trial evaluated tirzepatide in 2,539 adults with overweight or obesity over 72 weeks and demonstrated substantial reductions in body weight across the studied treatment groups.

Retatrutide

Retatrutide is an investigational triple-receptor agonist with activity at:

• GIP receptors
• GLP-1 receptors
• Glucagon receptors

A phase 2 randomized trial evaluated retatrutide for 48 weeks in adults with obesity and demonstrated substantial reductions in body weight across the studied treatment groups.

Retatrutide remains investigational and is not FDA-approved. Its regulatory status and availability differ from FDA-approved prescription medications.

Treatment Is Individualized

There Is No Universal PRO Protocol

The appropriate treatment cannot be determined by simply selecting a molecule from a website.

When prescription treatment is considered, your provider evaluates factors including:

• Medical history
• Current medications
• Previous weight-management treatments
• Current weight and body composition
• Body-fat and lean-mass goals
• Metabolic health
• Nutrition
• Exercise and activity
• Sleep and recovery
• Treatment response
• Medication tolerability
• Relevant laboratory findings
• Individual risk factors

Based on that information, a treatment plan can be developed specifically for the individual.

We do not publish universal medication protocols because treatment is designed around the patient.

Minimal Effective Treatment

More Medication Is Not Automatically Better

Our treatment philosophy emphasizes using the lowest effective treatment exposure that remains appropriate for the individual patient.

The objective is not simply to escalate medication because a higher dose exists.

Instead, treatment is continually evaluated according to:

• Clinical response
• Body-composition changes
• Appetite and nutritional intake
• Preservation of lean mass
• Side effects and tolerability
• Exercise performance
• Recovery
• Laboratory findings when appropriate
• Patient goals

When clinically appropriate, avoiding unnecessary medication escalation may also help reduce medication exposure and treatment cost.

90-Day Treatment Phases

PRO management is organized around structured 90-day treatment and reassessment phases.

Rather than beginning treatment and allowing it to continue indefinitely without defined checkpoints, we establish regular opportunities to evaluate the complete clinical picture.

Within the initial 90-day phase, patients can be reassessed at approximately:

DAY 0 — Baseline Assessment

DAY 30 — Response Review

DAY 60 — Progress & Treatment Review

DAY 90 — Comprehensive Reassessment

At each stage, the treatment plan can be maintained or adjusted based on the patient's progress, tolerability, goals, and medical needs.

At the end of the 90-day phase, the provider can determine whether treatment should remain unchanged, be adjusted, transitioned, or discontinued.

The objective is ongoing reassessment—not automatic dose escalation.

PRO FOUNDATIONS

The Preferred Starting Point for PRO Metabolic Management

For patients who want the most comprehensive approach, PRO Foundations is our primary pathway into ongoing metabolic and body-composition management.

Foundations brings together components that are often managed separately:

Medical oversight.
Body composition.
Nutrition.
Supplementation.
Laboratory data.
Sleep and recovery.
Activity.
Prescription and peptide management when clinically indicated.

Instead of evaluating success based only on the number on a scale, Foundations creates a structured system for understanding how your body is actually changing over time.

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What PRO Foundations Includes

Hume Band 2.0 + Hume Body Pod + 90 Days of PRO Monitoring

Your initial Foundations program includes:

• 1 × Hume Band 2.0
• 1 × Hume Body Pod
• Initial comprehensive intake and assessment
• Baseline body-composition evaluation
• Individual goal planning
• Nutrition guidance
• Supplement review and recommendations
• Laboratory review and testing when appropriate
• Prescription and peptide management when clinically indicated
• 30-day follow-up
• 60-day follow-up
• 90-day comprehensive review
• 90 days of PRO monitoring
• Hume mobile app integration
• Body-composition tracking
• Sleep and recovery tracking
• Activity monitoring
• Longitudinal progress analysis
• Treatment adjustments when appropriate

The objective is to create one connected system rather than treating weight, medication, nutrition, supplementation, activity, sleep, and recovery as unrelated variables.

EXPLORE THE COMPLETE PRO FOUNDATIONS PROGRAM

Your First 90 Days

DAY 0 — Establish the Baseline

Your Foundations program begins with a comprehensive intake and assessment.

Before deciding what needs to change, we first establish where you are now and where you want to go.

Your initial assessment may include:

• Current weight
• Body-fat percentage
• Lean mass
• Muscle mass
• Visceral fat
• Previous weight-management history
• Nutrition
• Protein intake
• Exercise and activity
• Sleep
• Recovery
• Current medications
• Current supplements
• Relevant medical history
• Previous laboratory testing
• Short- and long-term goals

From there, we establish the initial management strategy.

Prescription or peptide therapy may be incorporated only when medically appropriate and specifically indicated for the individual patient.

DAY 30 — Measure the Response

At approximately 30 days, we review what has actually happened.

Instead of asking only:

"How much weight did you lose?"

we evaluate a broader picture.

Depending on the patient's program and available data, that may include:

• Weight change
• Body-fat change
• Lean-mass change
• Muscle preservation
• Visceral-fat trends
• Appetite
• Nutritional intake
• Protein intake
• Activity
• Exercise
• Sleep
• Recovery
• Treatment adherence
• Medication response
• Medication tolerability
• Supplement use

The treatment plan can then be maintained or adjusted based on the patient's actual response.

DAY 60 — Monitor & Adjust

At approximately 60 days, we evaluate the trajectory of the program.

Are you losing body fat?

Are you maintaining lean mass?

Has appetite suppression become excessive?

Are you consuming adequate protein and overall nutrition?

Is exercise performance being maintained?

How is recovery?

How is sleep?

Is the current treatment still appropriate?

Do supplements need to be adjusted?

Is laboratory testing indicated?

Does medication management need to change?

These questions help determine whether the current strategy remains appropriate or should evolve.

DAY 90 — Comprehensive Reassessment

At approximately 90 days, we compare the current picture with the original baseline.

This provides considerably more information than simply comparing two numbers on a traditional scale.

We may review:

• Overall weight change
• Body-fat change
• Lean-mass preservation or development
• Visceral-fat trends
• Nutrition
• Exercise
• Sleep
• Recovery
• Medication response
• Medication tolerability
• Supplement strategy
• Relevant laboratory findings
• Progress toward the original goals

The next phase can then be developed around the individual's progress, goals, and clinical needs.

Nutrition Is Part of the Treatment

Weight Management Is More Than Eating Less

Reducing appetite without paying attention to nutrition can work against body-composition and performance goals.

During your consultation and follow-up visits, practical nutrition guidance may address:

• Protein intake and muscle preservation
• What to eat when appetite is reduced
• How much to eat when appetite is reduced
• Building balanced meals
• Hydration
• Digestion
• Meal timing
• Exercise nutrition
• Nutrition challenges associated with treatment
• Sustainable eating habits
• Long-term weight-management strategies

The objective is not simply to eat less.

It is to make sure the body continues receiving the nutrition necessary to support the patient's goals.

Targeted Supplementation

Supplements Should Have a Purpose

Supplementation can be incorporated into the larger Foundations strategy based on the patient's diet, goals, laboratory information, and treatment plan.

Depending on individual needs, supplementation may be considered in areas such as:

• Foundational micronutrient intake
• Protein and nutritional adequacy
• Omega-3 intake
• Magnesium intake
• Vitamin D status
• Exercise and recovery nutrition
• Other identified nutritional needs

Recommendations are individualized rather than automatically assigning every patient the same supplement regimen.

Laboratory Monitoring

Look Beyond the Scale

Laboratory testing may be incorporated when clinically appropriate.

Depending on the patient's history, treatment, symptoms, medications, and goals, laboratory evaluation can provide information that cannot be obtained from body weight or wearable data alone.

Testing may be completed through insurance when appropriate or through available cash-pay laboratory options.

The purpose is not to order unnecessary testing.

It is to use laboratory information when it can meaningfully inform treatment decisions.

Hume Body Pod

Understand What You're Actually Losing

A traditional scale tells you how much you weigh.

It does not tell you what changed.

The Hume Body Pod provides additional body-composition information that can help follow changes in:

• Body weight
• Body-fat percentage
• Lean body mass
• Muscle mass
• Visceral fat
• Body water
• Segmental body-composition information
• Long-term body-composition trends

This becomes particularly important during weight management.

A reduction in body weight accompanied by unnecessary loss of lean mass is very different from a reduction primarily driven by body fat.

The objective isn't simply a smaller number. It's a better body composition.

Hume Band 2.0

Understand What Happens Between Visits

The Hume Band 2.0 adds another layer of longitudinal information.

Depending on available Hume metrics and app functionality, tracked information may include:

• Daily activity
• Steps and movement
• Sleep duration
• Sleep quality
• Resting heart rate
• Heart-rate variability
• Recovery trends
• Exercise and activity patterns
• Long-term health trends

The Body Pod helps show what is changing.

The Band provides additional context around what is happening between measurements.

One Connected System

HUME BODY POD
Track body composition.

HUME BAND 2.0
Track activity, sleep, recovery, and daily trends.

HUME APP
Bring longitudinal data together in one ecosystem.

NUTRITION
Support adequate fueling, protein intake, muscle preservation, and sustainable habits.

SUPPLEMENTATION
Provide targeted nutritional support when appropriate.

LABORATORY TESTING
Provide additional objective information when clinically indicated.

PROVIDER MANAGEMENT
Provide medical oversight and ongoing clinical decision-making.

PRESCRIPTION / PEPTIDE MANAGEMENT
Incorporate treatment when medically appropriate and legally available.

Together, these components create the PRO Foundations feedback loop:

MEASURE → ANALYZE → ADJUST → REASSESS

And then repeat.

Built Around Better Body Composition

PRO Foundations can support individuals working toward goals such as:

• Reducing body fat
• Losing weight
• Building or preserving muscle
• Improving body composition
• Reducing visceral adiposity
• Improving exercise consistency
• Improving sleep and recovery
• Supporting metabolic health
• Improving physical performance
• Establishing sustainable long-term habits

The emphasis is not simply on achieving the lowest possible number on the scale.

It's about understanding what you're losing, what you're preserving, what you're building, and how your body is changing.

Start With PRO Foundations

More Than Medication

Medication can be one component of metabolic management.

It does not measure your body composition.

It does not tell you whether you are preserving muscle.

It does not evaluate your nutrition.

It does not monitor your sleep or recovery.

It does not interpret laboratory results.

And it does not replace individualized medical oversight.

PRO Foundations is designed to bring those pieces together.

For patients interested in comprehensive metabolic management, Foundations provides our preferred pathway for establishing a baseline, defining goals, monitoring progress, and determining whether additional interventions—including prescription or peptide management—are medically appropriate.

90 Days. 30-Day Monitoring. One Connected Plan.

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Prescription Access

Consultation Required

Prescription-limited treatment cannot be obtained simply by selecting an option on this website.

A specific medical consultation and appropriate provider evaluation are required before prescription treatment can be provided.

The provider determines:

• Whether treatment is medically appropriate
• Which treatment option, if any, is appropriate
• The appropriate individualized treatment plan
• Monitoring requirements
• Whether treatment should be continued or adjusted

A consultation does not guarantee that a prescription will be issued.

Specific treatment, formulation, dosing, dispensing, and availability are determined only after appropriate clinical evaluation and are subject to applicable prescribing and pharmacy requirements.

Where compounded medications are involved, they are not FDA-approved and are subject to applicable federal and state requirements.

THE PRO APPROACH

Measure. Monitor. Adjust. Progress.

The goal isn't to put every patient on the same medication.

It isn't to automatically increase the dose.

And it isn't to judge progress from a single number on a scale.

Our approach is to understand the individual, establish measurable goals, monitor the response, and make treatment decisions based on the clinical picture and objective data.

Individualized treatment.
Objective monitoring.
30-day accountability.
90-day reassessment.
Minimal effective treatment.

A plan built around the patient—not around the product.

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