GL-3 Molecule (RETA)

(Prescription Only) – 40mg

Triple-Incretin Therapy for Fat Loss, Appetite Control & Metabolic Optimization

Formulation

GL-3 Core 40

1 × 40mg GL-3 Vial

Each vial contains:

• 40mg GL-3

• 2mL total volume

• Concentration: 40mg / 2mL (20mg/mL)

Total Package Contents: 40mg GL-3 (2mL total)

Classification: Prescription Only – Requires Provider Consultation & Approval

What Is GL-3 Therapy?

GL-3 is a prescription triple-incretin therapy that activates three key metabolic pathways involved in appetite regulation, metabolism, and fat utilization:

• GLP-1 (Glucagon-Like Peptide-1)

• GIP (Glucose-Dependent Insulinotropic Polypeptide)

• Glucagon Receptor

Unlike traditional weight-loss therapies that primarily suppress appetite, GL-3 works through multiple metabolic pathways to improve body composition by reducing caloric intake while simultaneously increasing energy expenditure and promoting fat oxidation.

Potential benefits include:

• Significant appetite suppression

• Accelerated fat loss

• Improved insulin sensitivity

• Increased calorie expenditure

• Enhanced fat oxidation

• Improved metabolic flexibility

• Long-term body composition improvements

GL-3 represents the most advanced generation of incretin therapy and is intended for provider-directed metabolic optimization and sustained fat loss.

All GL-3 products require clinical consultation and prescription approval prior to dispensing.

🔬 Research-Based Mechanisms

🔥 Triple-Incretin Activation for Superior Fat Loss

GL-3 activates the GLP-1, GIP, and glucagon receptors simultaneously, creating complementary effects on appetite regulation, insulin sensitivity, and energy expenditure that exceed those seen with single-pathway therapies.

Potential benefits include:

• Reduced hunger

• Increased satiety

• Greater fat oxidation

• Increased calorie expenditure

• Improved preservation of lean body mass during weight loss

Jastreboff et al., 2023 (NEJM) demonstrated average body-weight reductions approaching 24.2% over 48 weeks.

🩸 Improved Glycemic Control & Insulin Sensitivity

GL-3 enhances glucose regulation by improving insulin responsiveness while reducing fasting glucose levels and HbA1c.

Potential benefits include:

• Improved insulin sensitivity

• Reduced fasting glucose

• Improved metabolic health

• Better nutrient partitioning

Frias et al., 2023 (Diabetes Care) demonstrated significant improvements in glycemic control.

🧠 Appetite Suppression & Craving Control

GL-3 acts on appetite centers within the brain to reduce hunger while decreasing food reward signaling.

Many patients report:

• Less frequent hunger

• Earlier fullness during meals

• Reduced cravings

• Easier adherence to calorie reduction

🧬 Increased Fat Oxidation & Energy Expenditure

Activation of the glucagon receptor increases the body's utilization of stored fat while helping maintain metabolic rate during weight loss.

Potential benefits include:

• Increased fat utilization

• Higher daily calorie expenditure

• Improved metabolic efficiency

• Enhanced body composition

⚕️ Clinical Access & Provider Oversight

GL-3 therapy requires ongoing provider supervision.

Treatment includes:

• Initial consultation

• Prescription approval

• Individualized dosing plan

• Titration based on response

• Follow-up monitoring

Recommended laboratory evaluation may include:

• HbA1c

• Fasting glucose

• Comprehensive metabolic panel (CMP)

• Lipid panel

💉 Dosing Protocol (GL-3 Core 40)

Continuation Therapy

GL-3 Core 40 is intended for patients who have already completed their initial titration and are established on higher weekly dosing.

This formulation is designed to reduce refill frequency while maintaining consistent therapy—not to extend treatment duration.

Typical weekly dosing ranges include:

Your provider will individualize dosing based on treatment response, body composition goals, and medication tolerance.

Dose Adjustments

Remain on the current dose while progress continues.

Your provider may recommend increasing by 5 units (1mg) if:

• Weight loss plateaus for two or more consecutive weeks

• Appetite suppression significantly diminishes

• Treatment continues to be well tolerated

If side effects occur:

• Reduce by 5 units (1mg)

• Remain at the lower dose until symptoms improve

• Resume upward titration only under provider guidance

Administration

• Route: Subcutaneous injection

• Preferred Site: Abdomen

• Rotate injection sites regularly.

Ideal Use

GL-3 Core 40 is specifically designed for patients requiring higher weekly dosing after successful titration through lower-dose therapy.

Rather than purchasing multiple smaller vials, patients can maintain uninterrupted treatment using a single higher-concentration vial.

Because this formulation is intended for established higher-dose therapy, most patients will utilize the entire vial within approximately 45–60 days, supporting both treatment continuity and appropriate handling after first puncture.

Approximate Treatment Duration

Actual duration will vary based on individualized provider-directed dosing.

Typical Program Length

GL-3 is commonly incorporated into a 3–12 month provider-guided metabolic optimization program, with reassessment every 4–8 weeks to evaluate progress, adjust dosing, and determine appropriate cycling strategies.

Compatible Therapy Stacks

KPV

Supports gastrointestinal health, gut barrier integrity, and inflammatory balance.

Tesamorelin

Supports body composition by stimulating endogenous growth hormone release, helping preserve lean muscle while reducing visceral abdominal fat.

MOTS-C

Enhances mitochondrial energy production, metabolic flexibility, insulin sensitivity, and exercise performance while supporting healthy fat utilization.

GHK-Cu

Supports tissue repair, recovery, and overall regenerative health.

📦 Every Order Includes

• 1 × 40mg GL-3 vial (2mL)

• Insulin syringes

• Alcohol swabs

• Sharps disposal bag

• Printed dosing, storage, mixing (if applicable), and injection guide

• Ongoing access to a licensed prescribing provider for treatment support

📧 Questions?

Admin@Propeptides.com

480-400-6225

🛡️ Advanced Fat Loss. Triple-Pathway Precision. Clinical Oversight.

GL-3 Core 40 is formulated for patients who have progressed to higher-dose therapy and require a more concentrated monthly supply to maintain momentum toward their body composition goals. By simultaneously activating the GLP-1, GIP, and glucagon receptors, GL-3 supports appetite regulation, increased fat oxidation, improved insulin sensitivity, and greater energy expenditure.

Designed for experienced patients utilizing higher weekly doses, GL-3 Core 40 delivers convenient dosing flexibility in a single concentrated vial while maintaining comprehensive provider oversight. When paired with individualized nutrition, resistance training, and regular follow-up, it provides an effective tool for achieving sustainable improvements in body composition and long-term metabolic health.