COMING SOON — PRE-PRODUCTION FORMULA

PRO METABOLIC is currently in development and is not yet available. Purchases will be placed on a PRE ORDER LIST.

Product images, ingredient amounts, serving size, capsule count, pricing, and other specifications shown on this page represent the proposed pre-production formulation and are provided for informational purposes only. Final formulation and product specifications may change prior to release.

Final product labeling and Supplement Facts will reflect the production formula available at launch.

PRO METABOLIC – Metabolic Support Complex

Targeted Daily Support for Glucose Metabolism, Insulin Sensitivity, Lipid Metabolism, and Overall Metabolic Health

PRO METABOLIC by PRO Therapeutics combines berberine HCl, alpha-lipoic acid (ALA), and Ceylon cinnamon extract in a targeted daily formula designed to support healthy glucose metabolism, insulin sensitivity, lipid metabolism, and overall metabolic function.

Each Proposed Daily Serving of Two Capsules Provides:

1,000 mg Berberine HCl
300 mg Alpha-Lipoic Acid (ALA)
250 mg Ceylon Cinnamon Extract

Rather than creating an oversized metabolic formula with numerous overlapping ingredients, PRO METABOLIC focuses on three researched compounds with complementary roles in metabolic physiology.

Human clinical research supports the potential metabolic effects of each ingredient. A 2024 systematic review and meta-analysis of 50 randomized controlled trials involving 4,150 participants found that berberine supplementation was associated with improvements in several glycemic and lipid measures in populations with type 2 diabetes. PubMed

Each proposed bottle contains 60 capsules, providing a complete 30-day supply at the standard two-capsule daily serving.

At PRO Therapeutics, METABOLIC is designed to add focused metabolic support to the broader Foundations approach:

Build the foundation. Support the metabolism. Optimize the outcome.

Key Benefits

Supports Healthy Glucose Metabolism

Glucose regulation is a fundamental component of metabolic health.

Berberine has been extensively investigated for its effects on glucose metabolism. A 2024 meta-analysis of 50 randomized controlled trials found that berberine used alone was associated with reductions in fasting glucose and 2-hour postprandial glucose. When studied alongside glucose-lowering medications, improvements were also reported in HbA1c, fasting insulin, and HOMA-IR. PubMed

An umbrella meta-analysis also reported reductions in fasting glucose, HbA1c, insulin, and HOMA-IR across previous berberine meta-analyses. PubMed

Potential nutritional support includes:

• Healthy glucose metabolism
• Normal insulin signaling
• Healthy insulin sensitivity
• Post-meal metabolic support
• Overall metabolic function

References

Wang J, Bi C, Xi H, Wei F. Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis. Front Pharmacol. 2024. PubMed

Nazari A, et al. The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-analysis of Randomized Controlled Trials. Clin Ther. 2024. PubMed

Supports Insulin Sensitivity

Insulin sensitivity influences how effectively the body responds to insulin and manages circulating glucose.

All three primary components of PRO METABOLIC have been investigated in this area.

Berberine research has reported improvements in HOMA-IR, a commonly used research marker of insulin resistance. PubMed

ALA has also been studied for metabolic support. A systematic review and dose-response meta-analysis of 16 randomized trials involving 1,035 participants with type 2 diabetes found improvements in several cardiometabolic measures with oral ALA supplementation, although effects differed across outcomes and doses. PubMed

Cinnamon provides a third complementary component. A meta-analysis of 24 randomized controlled trials reported reductions in fasting glucose, HOMA-IR, and HbA1c among participants with type 2 diabetes, though cinnamon research varies by preparation, dose, population, and study design. PubMed

Three ingredients. Three complementary approaches to metabolic support.

Supports Healthy Lipid Metabolism

Metabolic health extends beyond glucose.

Berberine has also been investigated for its effects on circulating lipids.

In the 2024 meta-analysis of 50 randomized controlled trials, berberine used alone was associated with reductions in:

• LDL cholesterol
• Total cholesterol
• Triglycerides PubMed

A separate systematic review and meta-analysis of 18 randomized placebo-controlled trials involving 1,788 participants similarly reported reductions in LDL cholesterol, total cholesterol, triglycerides, and apolipoprotein B. PubMed

ALA has also been evaluated for lipid effects, although findings vary among meta-analyses and patient populations. PubMed

PRO METABOLIC is therefore positioned as nutritional support for healthy metabolic and lipid physiology, not as a replacement for prescribed lipid-lowering or glucose-lowering therapy.

Berberine HCl

Proposed Daily Serving: 1,000 mg

Berberine is a naturally occurring plant alkaloid and the primary metabolic-support ingredient in PRO METABOLIC.

The proposed 1,000 mg daily dose sits within the dosage range commonly represented in clinical research. In the 2024 meta-analysis of 50 RCTs, the most common berberine dosage across included studies was approximately 0.9–1.5 grams per day, with treatment periods commonly lasting one to three months. PubMed

Berberine has been investigated for its effects on:

• Glucose metabolism
• Insulin sensitivity
• Lipid metabolism
• Metabolic signaling
• Overall cardiometabolic health

Reference

Wang J, et al. Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis. Front Pharmacol. 2024. PubMed

Alpha-Lipoic Acid (ALA)

Proposed Daily Serving: 300 mg

Alpha-lipoic acid is a naturally occurring compound involved in mitochondrial metabolism and cellular energy production.

ALA also possesses antioxidant properties and has been investigated for its effects on glucose metabolism, insulin sensitivity, oxidative stress, and other cardiometabolic parameters.

A systematic review and dose-response meta-analysis of randomized trials found oral ALA supplementation was associated with improvements in several metabolic measures, although the magnitude and consistency of effects varied according to outcome and dose. PubMed

A broader meta-analysis of 24 studies involving patients with metabolic diseases also reported improvements in several glucose-homeostasis and lipid measures. PubMed

In PRO METABOLIC, ALA complements berberine by adding mitochondrial and antioxidant nutritional support to the formula.

References

Jibril AT, Jayedi A, Shab-Bidar S. Efficacy and safety of oral alpha-lipoic acid supplementation for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized trials. Endocr Connect. 2022. PubMed

Ceylon Cinnamon Extract

Proposed Daily Serving: 250 mg

PRO METABOLIC completes the formula with Ceylon cinnamon extract (Cinnamomum verum).

Cinnamon has been investigated for its potential influence on glucose metabolism and insulin sensitivity.

A systematic review and meta-analysis of 24 randomized controlled trials found cinnamon supplementation was associated with improvements in fasting glucose, HOMA-IR, and HbA1c in people with type 2 diabetes. PubMed

An umbrella meta-analysis of 11 previous meta-analyses similarly reported improvements in fasting glucose, insulin, HOMA-IR, and HbA1c, although results across individual trials and formulations remain heterogeneous. PubMed

Using Ceylon cinnamon also gives METABOLIC a botanical component that complements the more concentrated berberine and ALA components.

References

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose-response meta-analysis of randomized controlled trials. 2023. PubMed

Formulation

PRO METABOLIC Metabolic Support Complex

Proposed 2-Capsule Daily Serving

Proposed Bottle Size

60 capsules

30 full daily servings

30-day supply

Final formulation, serving size, and capsule count remain subject to change prior to production.

Standard Dosing

2 Capsules Daily

The proposed dosing protocol is two capsules daily, preferably with food or as recommended by your healthcare professional.

PRO METABOLIC is intended to complement—not replace—the fundamentals of metabolic health:

Nutrition + Activity + Body Composition + Recovery + Monitoring

At the proposed serving:

2 capsules per day = 30 days per bottle

Choose Your Supply

PRO METABOLIC is being designed around the same 30-day and 90-day structure used throughout the PRO Therapeutics system.

30-Day Supply

1 Bottle

60 capsules

30 daily servings

Ideal for individuals beginning PRO METABOLIC or who prefer purchasing one month at a time.

90-Day Supply

3 Bottles

180 total capsules

90 daily servings

Designed for individuals incorporating metabolic supplementation into a consistent three-month health and nutrition strategy.

Final pricing will be established prior to release.

Why 90 Days?

Metabolic Health Is Built Through Consistency

PRO METABOLIC isn't designed as an occasional supplement taken only after a high-carbohydrate meal or during periods of poor nutrition.

It is intended to complement a consistent metabolic-health strategy.

Month 1
Establish consistent supplementation alongside nutrition and activity.

Month 2
Continue the routine while monitoring body composition, nutrition, exercise, and relevant health metrics.

Month 3
Complete a full 90 days of consistent metabolic support and evaluate progress within the broader health strategy.

This is particularly compatible with the PRO Foundations model, where data, body composition, lifestyle, nutrition, and laboratory markers can be evaluated over time rather than relying on supplementation alone.

The PRO Therapeutics Approach

PRO METABOLIC was designed around a simple concept:

Metabolic health is part of the foundation—not a separate goal.

Instead of combining a long list of trendy metabolic ingredients into one oversized formula, METABOLIC focuses on three purposeful components with human research behind them:

Berberine HCl
Primary glucose and lipid metabolic support.

Alpha-Lipoic Acid
Mitochondrial, antioxidant, and metabolic support.

Ceylon Cinnamon
Complementary botanical support for healthy glucose metabolism.

Within the PRO Therapeutics ecosystem:

PRO FOUNDATIONS
Establishes the daily micronutrient baseline.

PRO OMEGA+
Provides concentrated omega-3 and CoQ10 nutritional support.

PRO RESTORE
Adds focused magnesium and amino-acid support for muscle function, neuromuscular health, and recovery.

PRO METABOLIC
Adds targeted nutritional support for glucose metabolism, insulin sensitivity, and lipid metabolism.

Together, the system is designed to complement nutrition, exercise, recovery, body-composition management, laboratory monitoring, and individualized health optimization.

Who Should Consider PRO METABOLIC?

✔ Individuals focused on improving their overall metabolic-health strategy

✔ Those looking for nutritional support for healthy glucose metabolism

✔ Individuals seeking support for healthy insulin sensitivity

✔ Those focused on healthy lipid and triglyceride metabolism

✔ Individuals working on body composition alongside appropriate nutrition and exercise

✔ Those looking for a focused berberine + ALA + Ceylon cinnamon formula

✔ Individuals incorporating laboratory and metabolic monitoring into a broader health strategy

✔ Those building a comprehensive performance, health, or longevity program

What You Receive

30-Day Supply

✔ 1 bottle

✔ 60 capsules

✔ 30 two-capsule daily servings

✔ 1,000 mg Berberine HCl per proposed daily serving

✔ 300 mg Alpha-Lipoic Acid

✔ 250 mg Ceylon Cinnamon Extract

90-Day Supply

✔ 3 bottles

✔ 180 total capsules

✔ 90 two-capsule daily servings

✔ Three consecutive 30-day supplies

✔ The same daily Berberine + ALA + Ceylon Cinnamon formula

Final formulation and quantities remain subject to change prior to production.

Important Safety Information

Because PRO METABOLIC is specifically designed to influence nutritional pathways related to metabolic health, medication use deserves particular attention with this product.

Berberine may cause gastrointestinal effects, including nausea, abdominal discomfort, constipation, or diarrhea in some individuals. It also has the potential to interact with medications, and combining metabolically active supplements with prescription glucose-lowering therapy can require closer monitoring.

Individuals taking medications for diabetes, blood glucose, blood pressure, cholesterol, anticoagulation, or other chronic medical conditions should discuss this product with their healthcare professional before use.

Individuals who are pregnant or nursing should not use the product without guidance from an appropriately qualified healthcare professional.

PRO METABOLIC should not be used as a substitute for prescribed diabetes, lipid, cardiovascular, or other medical therapy.

Because the formulation remains in pre-production, final safety instructions will be based on the finalized ingredients, doses, and manufactured product.

Reference

Wang J, et al. Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis. Front Pharmacol. 2024. PubMed

Support the Metabolism. Strengthen the Foundation.

PRO METABOLIC by PRO Therapeutics brings together berberine HCl, alpha-lipoic acid, and Ceylon cinnamonin a focused formula designed to support healthy glucose metabolism, insulin sensitivity, lipid metabolism, and overall metabolic function.

1,000 mg Berberine + 300 mg ALA + 250 mg Ceylon Cinnamon. Every Day.

Available soon in proposed 30-Day and 90-Day Supply options.

Performance. Recovery. Optimization. starts with the Foundation.