GL-3 Molecule (Prescription Only) – 20mg

Triple-Incretin Therapy for Fat Loss, Appetite Control & Metabolic Optimization

Formulation

GL-3 Core 20

2 × 10mg GL-3 Vials

Each vial contains:

• 10mg GL-3

• 1mL total volume

• Concentration: 10mg / 1mL

Total Package Contents: 20mg GL-3 (2mL total)

Classification: Prescription Only – Requires Provider Consultation & Approval

What Is GL-3 Therapy?

GL-3 is a prescription triple-incretin therapy that activates three key metabolic pathways:

• GLP-1 (Glucagon-Like Peptide-1)

• GIP (Glucose-Dependent Insulinotropic Polypeptide)

• Glucagon Receptor

By targeting all three receptors simultaneously, GL-3 provides comprehensive metabolic signaling, leading to:

• Significant appetite suppression

• Accelerated fat loss

• Improved insulin sensitivity

• Increased energy expenditure

• Enhanced metabolic flexibility

• Long-term body composition improvements

GL-3 represents the most advanced tier of incretin-based therapy and is typically utilized for patients requiring longer-term, provider-directed metabolic intervention and sustained fat loss.

All GL-3 products require clinical consultation and prescription approval prior to dispensing.

🔬 Key Research-Based Mechanisms

🔥 Triple-Incretin Activation for Superior Fat Loss

Simultaneous activation of GLP-1, GIP, and glucagon receptors enhances satiety and drives adipose tissue reduction.

Jastreboff et al., 2023 (NEJM) – Demonstrated up to 24.2% total body-weight reduction over 48 weeks.

🩸 Improved Glycemic Control & Insulin Sensitivity

Reduces fasting glucose, improves insulin signaling, and lowers HbA1c.

Frias et al., 2023 (Diabetes Care) – Reported HbA1c reductions up to 2.2%.

🧠 Appetite Suppression & Craving Control

Reduces central appetite signaling and food reward pathways.

Killion et al., 2022 – Demonstrated reduced hedonic eating behavior in preclinical models.

🧬 Increased Fat Oxidation & Energy Expenditure

Glucagon receptor activation increases metabolic rate and fat utilization.

Gil-Lozano et al., 2021 – Showed preservation of metabolic rate with increased fat oxidation.

⚕️ Clinical Access & Prescription Protocol

GL-3 therapy requires provider oversight and prescription approval.

• Telehealth consultation required prior to dispensing

• Labs may be recommended (HbA1c, fasting glucose, lipid panel, IGF-1)

• Individualized dosing and titration plan

• Ongoing provider monitoring and follow-up included

💉 Dosing Protocol (GL-3 Core 20)

Total Dose

20mg Total GL-3

Package Contents

2 × 10mg vials

Concentration

10mg / 1mL

Dosing Equivalency

10 units = 1mg GL-3

Starting Dose

20 units weekly (2mg)

Titration Strategy (Standard PROPeptides Protocol)

• Maintain dose until 2 consecutive weeks of no weight loss

• Increase by 10 units (1mg) when appropriate

• If side effects occur, reduce dose by 10 units and resume titration

Administration

Route: Subcutaneous injection (abdomen preferred)

Ideal Use

The GL-3 Core 20 package is ideal for patients who have progressed beyond starter dosing and are utilizing approximately 40–50 units (4–5mg) weekly.

At these dosing levels, the package typically provides approximately one month of therapy, although actual duration will vary based on individualized dosing and provider-directed titration.

Program Length

Typically utilized as part of a 3–6 month provider-guided metabolic optimization program with reassessment every 4–8 weeks.

Compatible Stacks

KPV

Supports gut health and inflammation management.

Tesamorelin

May support body composition optimization and visceral fat reduction.

MOTS-C

Supports metabolic efficiency and insulin sensitivity.

GHK-Cu

Supports recovery and tissue support.

📦 What’s Included With Every Order

• 2 × GL-3 Core 10mg vials (20mg total)

• Insulin syringes & alcohol swabs

• Sharps container bag

• Printed dosing, titration, storage, and injection guide

• Ongoing access to licensed prescribing provider

📧 Need Assistance?

Admin@Propeptides.com

480-400-6225

🛡️ Advanced Fat Loss. Triple-Pathway Precision. Clinical Oversight.

GL-3 Core 20 is designed for patients who have advanced beyond introductory dosing and require a higher monthly supply to maintain consistent progress. Through triple-incretin activation and provider-guided dosing, GL-3 supports meaningful fat loss, appetite control, improved metabolic function, and long-term body composition improvement.

Commit to GL-3 Core 20 for sustained metabolic support and provider-guided weight loss optimization.